However, a few drug salts may have an added therapeutic effect. Most drug salts do not lend a therapeutic action to a drug other than enhancing how well it dissolves, is absorbed, or its formulation characteristics. tetracycline phosphate complex, 250 mg capsules. An example of this would be tetracycline hydrochloride, 250 mg capsules vs. There may be important differences in absorption, dosing, or uses.Īccording to FDA, drug products are considered pharmaceutical alternatives (not pharmaceutical equivalents) if they contain the same therapeutic moiety (active ingredient), but are different salts. If you plan on using a drug that exists in a different salt form from the one your doctor originally prescribed, be sure to get your healthcare provider’s approval before you make a substitution. Most drug salts are not automatically substitutable without an okay from your doctor or pharmacist. Note: as a percentage of salt form as a function of all medicinal compounds Can I switch around between different drug salts? Other advantages of drug salt formation include development of controlled-release dosage forms, improved stability to extend shelf life, targeted drug delivery in the gastrointestinal tract (stomach or intestine), improved taste, improved drug effectiveness, reduced pain on injection, ease of processing, and extended patent life. The choice of a salt in the lab is determined primarily by how acid or basic the chemical is (the pH), the safety of the ionized form, the intended use of the drug, how the drug is given (for example, by mouth, injection, or on the skin), and the type of dosage form (such as tablet, capsule, or liquid). Therefore, drugs are often chemically made into their salt forms to enhance how the drug dissolves, boost its absorption into your bloodstream, and increase its effectiveness. Many medications need to be water-soluble, too. Without absorption, a drug cannot have a therapeutic effect, so some forms require a salt. Drugs are often formed as a weak acid or base, but this drug form is not always optimal for dissolution or absorption into your body. Over 50% of all drug molecules used in medicine exist as salts, most frequently as the hydrochloride, sodium, or sulfate salts. You’ve given the pharmacist a prescription for your new diabetes medication called metformin hydrochloride, but when you receive your bottle and look it up on the internet, all you see is “metformin”, not “metformin hydrochloride.” Why is this? Is it the same drug your doctor ordered? What is “hydrochloride”? Why do some drugs exist in salt forms? Medically reviewed by Leigh Ann Anderson, PharmD. The most you’ll hear from the rapper will usually be on Twitter, where he’ll remain mysterious but also give fans a glimpse behind the curtain of what he has going on or what they should be excited about.Drug Names and Their Pharmaceutical Salts - Clearing Up the Confusion Check out the visuals, which were directed by Eliel Ford, up top.īefore dropping the track, Keem started his 2021 by sharing “No Sense” at the beginning of March.“Don’t be showin out when you with your mans, dawg/ Please don’t let me catch him on my ends, dawg/ It’s a thousand ways to misunderstand, dawg/ It’s a thousand ways that we can make amends, dawg,” Keem raps on “No Sense” as he warns his former-love not to try and show off around him.īaby Keem has a lot of noise around him, but his moves are largely silent. Keem also shared the music video for the track. Distorted piano chords are laid behind their bars, creating a smooth sound that can be heard on other Keem songs. Paired with a gradient brown cover that matches the aesthetic of other songs he’s dropped this year and prior, Keem and Travis both take turns talking about things they describe to be “durag activity,” playing on the name of the song.
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